Home LiteratureArticle Details
PMID: 6182349 Published · ppublish English Journal Article

The demonstration of histamine release in clinical conditions: a review of past and present assay procedures.

Klinische Wochenschrift ·Vol. 60 ·No. 17 ·1982-09-01 ·Pages 873-81

Beaven MA, Robinson-White A, Roderick NB, Kauffman GL

Abstract

Topics related to the measurement of histamine in human plasma and other body fluids are reviewed. These include (1) an overview of the data obtained by the biological, fluorometric and radioenzymatic assays over the past 45 years; (2) the various modifications of the radioenzymatic isotopic assay of histamine and the development of a single extraction step assay; (3) a compilation of values obtained in our laboratory by the radioenzymatic assay of histamine levels in various body fluids in disease states associated with abnormal histamine production or release; and (4) factors that affect histamine levels in plasma and some experimental considerations for monitoring changes in free histamine levels. The last topic includes a discussion of the halflife of histamine in the circulation, its clearance across various vascular beds, and the fact that capillary endothelial cells are one site of inactivation of circulating histamine.

MeSH Terms
Animals Biological Assay Carbon Radioisotopes Fluorometry Guinea Pigs Histamine/analysis Histamine N-Methyltransferase Histamine Release Humans Methods Rats S-Adenosylmethionine Specimen Handling Tritium
Chemicals
Carbon Radioisotopes Tritium S-Adenosylmethionine Histamine Histamine N-Methyltransferase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Beaven M A
Robinson-White A
Roderick N B
Kauffman G L
References (52)
52 references, click to expand
  1. Histamine: its role in physiological and pathological processes.
    Monogr Allergy. 1978;13:1-113 PMID: 362171
  2. ELEVATION OF PLASMA HISTAMINE LEVELS IN THE DOG FOLLOWING ADMINISTRATION OF MUSCLE RELAXANTS, OPIATES AND MACROMOLECULAR POLYMERS.
    J Pharmacol Exp Ther. 1964 Jan;143:131-6 PMID: 14118078
  3. In vivo studies of the pathogenesis of cold urticaria, cholinergic urticaria, and vibration-induced swelling.
    J Invest Dermatol. 1976 Sep;67(3):327-32 PMID: 61247
  4. Measurement and normal range of free histamine in human blood plasma.
    Biochem Pharmacol. 1968 Nov;17(11):2271-80 PMID: 4975854
  5. HISTAMINE IN HUMAN URINE.
    Int Arch Allergy Appl Immunol. 1965;26:1-17 PMID: 14275096
  6. A sensitive and specific method for the determination of histomine in human whole blood and plasma.
    Hoppe Seylers Z Physiol Chem. 1972 Jun;353(6):911-20 PMID: 4626442
  7. Assessment of tissue fluid histamine levels in patients with urticaria.
    J Allergy Clin Immunol. 1978 Jun;61(6):350-4 PMID: 659726
  8. Effect of diet on urinary excretion of histamine.
    J Appl Physiol. 1954 Jan;6(7):387-92 PMID: 13117769
  9. FURTHER OBSERVATIONS ON THE URINARY EXCRETION OF HISTAMINE DURING AND AFTER NORMAL PREGNANCY.
    Acta Obstet Gynecol Scand. 1964;43:206-13 PMID: 14248203
  10. On histamine in cotton dust, and in the blood of cotton workers.
    J Hyg (Lond). 1937 Apr;37(2):234-42 PMID: 20475374
  11. Histamine release in clinical conditions.
    Mt Sinai J Med. 1978 May-Jun;45(3):357-86 PMID: 79135
  12. The distribution and fate of radioactive histamine in the rat.
    J Physiol. 1959 Oct;147:437-49 PMID: 14399150
  13. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge.
    N Engl J Med. 1976 Mar 25;294(13):687-90 PMID: 55969
  14. Liberation of histamine during reactive hyperaemia and muscle contraction in man.
    J Physiol. 1944 Dec 15;103(3):297-305 PMID: 16991647
  15. Urinary excretion of histamine, methylhistamine and methylimidazoleacetic acids in man under standardized dietary conditions.
    Scand J Clin Lab Invest Suppl. 1968;104:59-68 PMID: 4974103
  16. High-performance liquid-chromatographic separation and fluorescence measurement of biogenic amines in plasma, urine, and tissue.
    Clin Chem. 1978 Aug;24(8):1317-24 PMID: 679455
  17. Does the urinary excretion of imidazole acetic acid reflect the endogenous histamine metabolism in man?
    Acta Physiol Scand. 1961 Jan;51:41-6 PMID: 13725009
  18. An improved radioenzymatic assay for histamine in human plasma, whole blood, urine, and gastric juice.
    Ann Clin Biochem. 1979 Sep;16(5):259-64 PMID: 42342
  19. A study of histamine in myeloproliferative disease.
    Blood. 1966 Dec;28(6):795-806 PMID: 5959473
  20. Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.
    Anal Biochem. 1979 Apr 15;94(2):425-30 PMID: 111579
  21. Application of the enzymatic double isotope dilution assay for the study of histamine in plasma.
    J Pharmacol Exp Ther. 1970 Oct;175(1):228-34 PMID: 4919337
  22. Plasma and sweat histamine concentrations after heat exposure and physical exercise.
    J Appl Physiol. 1966 Mar;21(2):631-5 PMID: 5934472
  23. Liberation of histamine in man. Gas chromatography of ring methylated imidazoleacetic acids in urine.
    Scand J Clin Lab Invest. 1966;18(6):603-16 PMID: 4163667
  24. Effects of adrenergic agents, theophylline and other drugs on dextran edema and histamine release in rats.
    Biochem Pharmacol. 1974 Apr 1;23 (7):1211-7 PMID: 4132694
  25. Studies on the histamine content of blood, with special reference to leukemia, leukemoid reactions and leukocytoses.
    Blood. 1950 Jul;5(7):623-47 PMID: 15426646
  26. Plasma histamine concentrations in allergic diseases.
    J Allergy. 1963 Jan-Feb;34:8-15 PMID: 13969926
  27. Histamine in human blood. Determined by spectrofluorometry.
    Scand J Clin Lab Invest. 1963;15:173-8 PMID: 14002964
  28. Hormonal and hemodynamic profile of an anaphylactic reaction in man.
    Circulation. 1981 Jan;63(1):210-3 PMID: 7002360
  29. In vivo studies of mediator release in cold urticaria and cholinergic urticaria.
    J Allergy Clin Immunol. 1975 Jun;55(6):394-402 PMID: 48522
  30. Urinary excretion of histamine in healthy human subjects.
    Scand J Clin Lab Invest. 1956;8(4):296-303 PMID: 13390830
  31. A method of estimating histamine in plasma.
    Br J Pharmacol Chemother. 1957 Dec;12(4):397-405 PMID: 13489164
  32. A fluorometric method to determine levels of histamine in human plasma.
    J Allergy. 1961 May-Jun;32:236-40 PMID: 13729351
  33. Urinary histamine and urine volume in man.
    J Pharm Pharmacol. 1971 Sep;23(9):728 PMID: 4398263
  34. The continuous bioassay of the release and disappearance of histamine in the circulation.
    Br J Pharmacol. 1973 Nov;49(3):543-53 PMID: 4777714
  35. Blood and urine histamine levels in normal and pathological states as measured by a radiochemical assay.
    Clin Chim Acta. 1977 Sep 1;79(2):447-56 PMID: 890980
  36. Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine.
    Clin Chim Acta. 1972 Mar;37:91-103 PMID: 5022125
  37. Distribution of histamine among leukocytes and platelets.
    Blood. 1955 May;10(5):467-81 PMID: 14363327
  38. Increased production of prostaglandin D2 in patients with systemic mastocytosis.
    N Engl J Med. 1980 Dec 11;303(24):1400-4 PMID: 6107852
  39. Distribution of histamine and histaminase (diamine oxidase)d in blood of various species.
    Comp Biochem Physiol C. 1980;67C(2):187-90 PMID: 6108183
  40. Time course of histamine release and edema formation in the rat paw after thermal injury.
    Eur J Pharmacol. 1974 Aug;27(3):305-12 PMID: 4138054
  41. Histamine levels in plasma, blood, and urine in severe asthma, and the effect of corticosteroid treatment.
    Thorax. 1976 Dec;31(6):724-9 PMID: 1013943
  42. A method for the fluorometric assay of histamine in tissues.
    J Pharmacol Exp Ther. 1959 Nov;127:182-6 PMID: 14446178
  43. Role of histamine in the hypotensive action of d-tubocurarine in humans.
    Anesthesiology. 1981 Jul;55(1):19-25 PMID: 6166217
  44. A sensitive and specific enzymatic isotopic assay for tissue histamine.
    J Pharmacol Exp Ther. 1966 Sep;153(3):544-9 PMID: 5950817
  45. Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO).
    Biochem Pharmacol. 1980 Oct 15;29(20):2897-900 PMID: 6449204
  46. Anaphylactoid reactions to anesthetic drugs.
    Anesthesiology. 1981 Jul;55(1):3-5 PMID: 6166218
  47. Biologic implications of the structural and functional characteristics of the chemical mediators of immediate-type hypersensitivity.
    Harvey Lect. 1979;73:93-161 PMID: 396278
  48. The urinary excretion of subcutaneously injected histamine.
    Br J Pharmacol Chemother. 1956 Dec;11(4):462-6 PMID: 13383129
  49. A single-isotope enzyme assay for histamine.
    Anal Biochem. 1972 Mar;46(1):85-90 PMID: 5062882
  50. Measurement of urinary histamine: development of methodology and normal values.
    J Allergy Clin Immunol. 1981 Apr;67(4):305-11 PMID: 7204786
  51. Studies on histamine in human urine using a fluorometric method of assay.
    Clin Chim Acta. 1962 Jul;7:488-97 PMID: 14480944
  52. An automated continuous-flow system for the extraction and fluorometric analysis of histamine.
    Anal Biochem. 1974 Feb;57(2):383-94 PMID: 4819732
Article Info
Journal
Klinische Wochenschrift
Abbr.
Klin Wochenschr
ISSN
0023-2173
DOI
10.1007/BF01716943
Published
1982-09-01
Pages
873-81
Language
English
Region
Germany
NLM ID
2985205R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01716943
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2