Intragenic amplification and divergence in the mouse alpha-fetoprotein gene.

Nature ·Vol. 294 ·No. 5843 ·1981-12-24 ·Pages 713-8

Eiferman FA, Young PR, Scott RW, Tilghman SM

Abstract

The DNA sequences of the 14 exon junctions in the murine alpha-fetoprotein gene were determined using cloned genomic DNA. When these exons were examined with respect to the polypeptide segments they encoded, a direct correspondence between a threefold repeat of four exons and three protein domains was observed. Nucleotide sequence comparisons among the four exons of each domain were used to deduce the likely structure of the primordial domain, and the order and mechanism of its triplication to form the tripartite ancestral gene from which both alpha-fetoprotein and serum albumin arose. Sequence homologies among the four exons that constitute a single domain also suggest that they were derived, at least in part, from a common sequence which underwent successive amplification and divergence.

MeSH Terms

Animals Base Sequence Biological Evolution Gene Amplification Genes Mice RNA Splicing Recombination, Genetic Serum Albumin/genetics Structure-Activity Relationship alpha-Fetoproteins/genetics,physiology

Chemicals

Serum Albumin alpha-Fetoproteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Eiferman F A

Young P R

Scott R W

Tilghman S M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/294713a0

Published

1981-12-24

Pages

713-8

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

J00348, M16381, M16382, M16383, M16384, M16385, M16386, M16387, M16388, M16389, M16390, M16391, M16392, M16393, M16394, M16395

External Links

PubMed source DOI: 10.1038/294713a0 View journal details

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Intragenic amplification and divergence in the mouse alpha-fetoprotein gene.

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