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PMID: 6170266 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Keratin polypeptide modifications induced by human papilloma viruses (HPV).

Archives of dermatological research ·Vol. 271 ·No. 1 ·1981-00-00 ·Pages 83-90

Staquet MJ, Viac J, Thivolet J

Abstract

The keratin polypeptide composition of different types of warts was studied by means of SDS polyacrylamide gel electrophoresis. It was composed of five main polypeptides, similar to those found in normal epidermis (mol. wt. 67K to 55K) and an additional polypeptide (72K) was often detected. The distribution of each polypeptide was expressed as percentage of total keratins in the different samples. The most characteristic feature observed in warts was the marked decrease of the 67K polypeptide. There were increased amounts of the 67K-63K proteins and some difference was observed in the distribution of these proteins in the different types of warts. Thus, the viral infection seems mainly to modify the proteins which are only involved in the latest stages of the differentiation of keratinocytes.

MeSH Terms

Cell Transformation, Viral Electrophoresis, Polyacrylamide Gel Humans Keratins/biosynthesis Papillomaviridae/pathogenicity Peptide Biosynthesis Warts/metabolism,microbiology

Chemicals

Keratins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Staquet M J

Viac J

Thivolet J

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28 references, click to expand

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Article Info

Journal

Archives of dermatological research

Abbr.

Arch Dermatol Res

ISSN

0340-3696

DOI

10.1007/BF00417391

Published

1981-00-00

Pages

83-90

Language

English

Region

Germany

NLM ID

8000462

Subset

External Links

PubMed source DOI: 10.1007/BF00417391 View journal details

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