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PMID: 6166527 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes.

Hoppe-Seyler's Zeitschrift fur physiologische Chemie ·Vol. 362 ·No. 5 ·1981-05-00 ·Pages 549-56

Grinde B, Seglen PO

Abstract

Colchicine and vinblastine, two well known inhibitors of microtubular function, inhibited endogenous protein degradation as well as protein secretion and the degradation of an exogenous, internalized protein (asialo fetuin), in isolated rat hepatocytes. The inhibitors appeared to selectively affect the lysosomal pathway of degradation, since their effects were not additive to that of ammonia, a lysosomotropic degradation inhibitor.

MeSH Terms

Ammonium Chloride/pharmacology Animals Asialoglycoproteins Cells, Cultured Colchicine/pharmacology Fetuins Kinetics Liver/metabolism Lysosomes/drug effects,metabolism Male Microtubules/physiology Proteins/metabolism Rats Vinblastine/pharmacology alpha-Fetoproteins/metabolism

Chemicals

Asialoglycoproteins Fetuins Proteins alpha-Fetoproteins asialofetuin Ammonium Chloride Vinblastine Colchicine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Grinde B

Seglen P O

Article Info

Journal

Hoppe-Seyler's Zeitschrift fur physiologische Chemie

Abbr.

Hoppe Seylers Z Physiol Chem

ISSN

0018-4888

DOI

10.1515/bchm2.1981.362.1.549

Published

1981-05-00

Pages

549-56

Language

English

Region

Germany

NLM ID

2985060R

Subset

External Links

PubMed source DOI: 10.1515/bchm2.1981.362.1.549 View journal details

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Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes.

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