Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.

British journal of pharmacology ·Vol. 73 ·No. 3 ·1981-07-00 ·Pages 755-8

Carpenter SE, Lynn B

Abstract

1 Immediately after several topical applications of capsaicin at 2-hourly intervals, human forearm skin would no longer develop flare (vasodilation) around a small injury. At the same time heat pain thresholds were reduced on average by 3.5 degrees C. These results are consistent with block by capsaicin of the effector side of the axon reflex, perhaps by depleting nerve terminals of substance P. 2 Over a period from several days to several weeks after treatment, flare was diminished and heat pain thresholds were slightly elevated. These changes may be due to long-lasting damage of cutaneous nerve terminals by capsaicin.

MeSH Terms

Administration, Topical Axons/physiology Capsaicin/pharmacology Differential Threshold Fatty Acids, Unsaturated/pharmacology Humans Pain/physiopathology Reflex/drug effects Sensation/drug effects Skin/blood supply,drug effects,injuries Substance P/pharmacology Vasodilation/drug effects

Chemicals

Fatty Acids, Unsaturated Substance P Capsaicin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Carpenter S E

Lynn B

References (10)

10 references, click to expand

Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin.
Naunyn Schmiedebergs Arch Pharmacol. 1975;287(2):157-69 PMID: 1143357
Modification by capsaicin and compound 48/80 of dye leakage induced by irritants in the rat.
Br J Pharmacol. 1977 Jan;59(1):61-8 PMID: 556966
Autonomic neuroeffector junctions--reflex vasodilatation of the skin.
J Invest Dermatol. 1977 Jul;69(1):47-57 PMID: 17640
A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain.
J Physiol (Paris). 1977 Sep;73(3):251-9 PMID: 926026
Flare and itch induced by substance P in human skin.
J Invest Dermatol. 1978 Oct;71(4):233-5 PMID: 81243
Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin.
Br J Pharmacol. 1980 Feb;68(2):207-13 PMID: 6153545
Substance P as a transmitter candidate.
Annu Rev Neurosci. 1980;3:227-68 PMID: 6158283
Direct evidence for an axonal site of action of capsaicin.
Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(1):91-4 PMID: 7207640
Inflammatory peptide in spinal cord: evidence that the mediator of antidromic vasodilatation is not substance P.
Neurosci Lett. 1980 May 15;18(1):99-103 PMID: 6189015
The nature and the distribution of afferent fibres provided with the axon reflex arrangement.
Acta Physiol Scand. 1953 Nov 17;29(4):359-70 PMID: 13123994

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1981.tb16812.x

Published

1981-07-00

Pages

755-8

Language

English

Region

England

NLM ID

7502536

PMCID

PMC2071711

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1981.tb16812.x PMC Full Text View journal details

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Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.

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