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PMID: 6163495 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Characterization of the rat parotid beta-adrenoceptor.

British journal of pharmacology ·Vol. 72 ·No. 2 ·1981-02-00 ·Pages 271-6

Carlsöö B, Danielsson A, Henriksson R, Idahl LA

Abstract

1 The effects of various beta-adrenoceptor agonists on amylase secretion from the rat parotid gland were studied by means of two different in vitro techniques. 2 The dose-response relation for each agonist was established, as also were the ED50 values. 3 All drugs appeared to act directly on the acinar cells, as reserpine-treatment did not abolish their secretagogic effects. 4 Two groups of agonists could be distinguished: one group consisting of adrenaline, noradrenaline and the B1-selective agonist prenalterol (H133/22) with a high enzyme discharge potency and a second group consisting of the beta 2-agonists, terbutaline and salbutamol, with a markedly lower effect. 5 The present data further support the theory that rat parotid acinar cells are supplied mainly with beta-adrenoceptors of the beta 1-subtype, similar to those present in heart and adipose tissue.

MeSH Terms
Adrenergic beta-Agonists/pharmacology Amylases/metabolism Animals Catecholamines/pharmacology Dinitrophenols/pharmacology Female Parotid Gland/metabolism Rats Receptors, Adrenergic/metabolism Receptors, Adrenergic, beta/metabolism Reserpine/pharmacology Uncoupling Agents/pharmacology
Chemicals
Adrenergic beta-Agonists Catecholamines Dinitrophenols Receptors, Adrenergic Receptors, Adrenergic, beta Uncoupling Agents Reserpine Amylases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Carlsöö B
Danielsson A
Henriksson R
Idahl L A
References (17)
17 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1981.tb09124.x
Published
1981-02-00
Pages
271-6
Language
English
Region
England
NLM ID
7502536
PMCID
PMC2071516
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1981.tb09124.x PMC Full Text View journal details
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