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PMID: 6162860 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Heterogeneity of DNA deletion in gamma delta beta-thalassemia.

The Journal of clinical investigation ·Vol. 67 ·No. 3 ·1981-03-00 ·Pages 878-84

Orkin SH, Goff SC, Nathan DG

Abstract

By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.

MeSH Terms
Base Sequence Chromosome Deletion DNA Restriction Enzymes Fetal Hemoglobin/genetics Genes Globins/genetics Hemoglobin A/genetics Humans Thalassemia/classification,genetics
Chemicals
Globins Hemoglobin A Fetal Hemoglobin DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Orkin S H
Goff S C
Nathan D G
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22 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/jci110105
Published
1981-03-00
Pages
878-84
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC370639
Subset
IM
Databases
GENBANK
J00093, J00094, J00096, J00158, J00159, J00160, J00161, J00162, J00163, J00164, J00165, J00166, J00167, J00168, J00169, J00170, J00171, J00172, J00173, J00174, J00175, J00177, J00178, J00179, K01239, K01890, K02544, M18047, M19067, X00423
External Links
PubMed source DOI: 10.1172/jci110105 PMC Full Text View journal details
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