The action of Nupercaine on calcium efflux from rat liver mitochondria.

The Biochemical journal ·Vol. 188 ·No. 3 ·1980-06-15 ·Pages 749-55

Dawson AP, Fulton DV

Abstract

1. Nupercaine inhibits the Ca2+ efflux from rat liver mitochondria observed in the presence of Ruthenium Red, 50% inhibition being obtained at 80 microM-Nupercaine. 2. Neither the Ruthenium Red-stimulated efflux nor its inhibition by Nupercaine can be directly attributed to effects on mitochondrial stability. 3. Nupercaine perturbs the steady-state external Ca2+ concentration in the absence of Ruthenium Red to an extent that is explicable in terms of the inhibition of Ca2+ efflux. 4. Various factors that are likely to be involved in determining steady-state extra-mitochondrial Ca2+ concentrations are discussed.

MeSH Terms

Animals Biological Transport, Active/drug effects Calcium/metabolism Depression, Chemical Dibucaine/pharmacology In Vitro Techniques Intracellular Membranes/drug effects,metabolism Kinetics Membrane Potentials/drug effects Mitochondria, Liver/drug effects,metabolism Rats Ruthenium Red/pharmacology

Chemicals

Ruthenium Red Dibucaine Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Dawson A P

Fulton D V

References (26)

26 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1880749

Published

1980-06-15

Pages

749-55

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1161957

Subset

External Links

PubMed source DOI: 10.1042/bj1880749 PMC Full Text View journal details

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The action of Nupercaine on calcium efflux from rat liver mitochondria.

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