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PMID: 6160591 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 10 ·1980-10-00 ·Pages 6101-4

Markert ML, Cresswell P

Abstract

The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (alpha) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (beta) or a crossreactive determinant(s) on the HLA-DR3 alpha subunit and an additional alpha subunit. MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.

MeSH Terms
B-Lymphocytes/immunology Epitopes HLA Antigens/genetics Histocompatibility Antigens Class II/genetics Humans Isoantigens/genetics Macromolecular Substances Major Histocompatibility Complex Polymorphism, Genetic
Chemicals
Epitopes HLA Antigens Histocompatibility Antigens Class II Isoantigens Macromolecular Substances
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Markert M L
Cresswell P
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29 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.10.6101
Published
1980-10-00
Pages
6101-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350221
Subset
IM
Grants
NIAID NIH HHS · AI-08897 · United States
NIAID NIH HHS · AI-14016 · United States
External Links
PubMed source DOI: 10.1073/pnas.77.10.6101 PMC Full Text View journal details
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