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PMID: 6157774 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Defective B cell tolerance in adult (NZB X MZW)F1 mice.

The Journal of experimental medicine ·Vol. 152 ·No. 3 ·1980-09-01 ·Pages 730-5

Goldings EA, Cohen PL, McFadden SF, Ziff M, Vitetta ES

Abstract

Hapten-specific tolerance was induced in vitro by trinitrophenyl-human gamma globulin (TNP32HGG) to a comparable degree in B cells from adult autoimmune (NZB X NZW)F1 (B/W) mice and normal BDF1, CBA/J, and DBA/1J mice. When a lower epitope density tolerogen (TNP7HGG) was used, B/W mice were significantly less sensitive than normal mice to the induction of B cell tolerance. This finding of defective B cell tolerance in adult B/W mice is consistent with previous reports that document other B cell abnormalities that may relate to the expression of autoimmune disease.

MeSH Terms

Animals Antibody Formation B-Lymphocytes/immunology Dose-Response Relationship, Immunologic Epitopes Immune Tolerance Mice Mice, Inbred NZB/immunology Mice, Inbred Strains/immunology Spleen/immunology Trinitrobenzenes/immunology

Chemicals

Epitopes Trinitrobenzenes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Goldings E A

Cohen P L

McFadden S F

Ziff M

Vitetta E S

References (23)

23 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.152.3.730

Published

1980-09-01

Pages

730-5

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2185913

Subset

Grants

NIAID NIH HHS · AI-11851 · United States

NIAID NIH HHS · AI-12789 · United States

NIADDK NIH HHS · AM-09989 · United States

External Links

PubMed source DOI: 10.1084/jem.152.3.730 PMC Full Text View journal details

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Defective B cell tolerance in adult (NZB X MZW)F1 mice.

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