Inhibition of histamine release induced by compound 48/80 and peptide 401 in the presence and absence of calcium. Implications for the mode of action of anti-allergic compounds.

Agents and actions ·Vol. 10 ·No. 3 ·1980-06-00 ·Pages 222-8

Ennis M, Atkinson G, Pearce FL

Abstract

Histamine may be released from rat peritoneal mast cells by compound 48/80 and peptide 401 in the presence and absence of extracellular calcium. The process is non-cytolytic and requires an intact cell metabolism. The release produced under both conditions is inhibited by disodium cromoglycate, theophylline, dibutyryl cyclic AMP and (at high concentrations) quercetin. The efficacy of the drugs in the absence of extracellular calcium cannot be explained in terms of their postulated effect on the calcium-gating mechanism operative in anaphylactic secretion. Alternative modes of action of the compounds are thus considered.

MeSH Terms

Animals Bee Venoms/pharmacology Bucladesine/pharmacology Calcium/metabolism,pharmacology Cromolyn Sodium/pharmacology Dose-Response Relationship, Drug Female Glycolysis Histamine Antagonists/pharmacology Histamine Release/drug effects Hypersensitivity/drug therapy Male Peptides/pharmacology Quercetin/pharmacology Rats Theophylline/pharmacology p-Methoxy-N-methylphenethylamine/pharmacology

Chemicals

Bee Venoms Histamine Antagonists Peptides mast cell degranulating peptide p-Methoxy-N-methylphenethylamine Bucladesine Quercetin Theophylline Cromolyn Sodium Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ennis M

Atkinson G

Pearce F L

References (21)

21 references, click to expand

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Article Info

Journal

Agents and actions

Abbr.

Agents Actions

ISSN

0065-4299

DOI

10.1007/BF02025939

Published

1980-06-00

Pages

222-8

Language

English

Region

Switzerland

NLM ID

0213341

Subset

External Links

PubMed source DOI: 10.1007/BF02025939

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Inhibition of histamine release induced by compound 48/80 and peptide 401 in the presence and absence of calcium. Implications for the mode of action of anti-allergic compounds.

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