Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover.

3',5'-Cyclic-GMP Phosphodiesterases/analysis Animals Aorta/drug effects Cyclic GMP/metabolism,pharmacology Drug Tolerance Guanylate Cyclase/analysis In Vitro Techniques Male Nitroglycerin/pharmacology Protein Kinases/analysis Rats Rats, Inbred Strains

Protein Kinases 3',5'-Cyclic-GMP Phosphodiesterases Guanylate Cyclase Nitroglycerin Cyclic GMP