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PMID: 6107911 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 8 ·1980-08-00 ·Pages 5021-4

Pearson D, Shively JE, Clark BR, Geschwind II, Barkley M, Nishioka RS, Bern HA

Abstract

Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its structure. Urotensin II from Gillichthys is a 1363-dalton dodecapeptide with the amino acid sequence Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val. This sequence is homologous with somatostatin in positions 1 and 2 and 7-9. The sequence has been verified by the production of a bioactive synthetic urotensin II. The possible chemical and physiological significance of its homology to somatostatin is discussed.

MeSH Terms
Amino Acid Sequence Animals Chromatography, High Pressure Liquid Fishes/physiology Neurosecretory Systems/analysis Peptides/isolation & purification Somatostatin/analysis Structure-Activity Relationship Urotensins/isolation & purification
Chemicals
Peptides Urotensins Somatostatin
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Pearson D
Shively J E
Clark B R
Geschwind I I
Barkley M
Nishioka R S
Bern H A
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19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.8.5021
Published
1980-08-00
Pages
5021-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349982
Subset
IM
Grants
PHS HHS · 16434 · United States
NICHD NIH HHS · HD-00394 · United States
NINDS NIH HHS · NS13644 · United States
External Links
PubMed source DOI: 10.1073/pnas.77.8.5021 PMC Full Text View journal details
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