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PMID: 6105342 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Propranolol--a medical treatment for portal hypertension?

Lancet (London, England) ·Vol. 2 ·No. 8187 ·1980-07-26 ·Pages 180-2

Lebrec D, Nouel O, Corbic M, Benhamou JP

Abstract

Continuous, oral administration of propranolol at doses which reduced the heart-rate by 25% produced a sustained decrease in portal venous pressure in cirrhotic patients with portal hypertension. This effect of propranolol might be useful in preventing recurrent bleeding due to ruptured oesophageal varices in patients with portal hypertension.

MeSH Terms
Administration, Oral Cardiac Output/drug effects Clinical Trials as Topic Esophageal and Gastric Varices/complications Gastrointestinal Hemorrhage/prevention & control Heart Rate/drug effects Humans Hypertension, Portal/drug therapy Liver Circulation/drug effects Propranolol/administration & dosage,therapeutic use Venous Pressure/drug effects
Chemicals
Propranolol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lebrec D
Nouel O
Corbic M
Benhamou J P
Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
0140-6736
DOI
10.1016/s0140-6736(80)90063-x
Published
1980-07-26
Pages
180-2
Language
English
Region
England
NLM ID
2985213R
Subset
IM
External Links
PubMed source DOI: 10.1016/s0140-6736(80)90063-x View journal details
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