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PMID: 6102627 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Clavulanic acid and amoxycillin: a clinical, bacteriological, and pharmacological study.

Lancet (London, England) ·Vol. 1 ·No. 8169 ·1980-03-22 ·Pages 620-3

Ball AP, Geddes AM, Davey PG, Farrell ID, Brookes GR

Abstract

Clavulanic acid is an inhibitor of certain beta-lactamases, notably those enzymes which inactivate the penicillins and cause resistance of important bacteria to these antibiotics. Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and safe in the treatment of urinary-tract infection caused by amoxycillin-resistant bacteria.

MeSH Terms
Administration, Oral Amoxicillin/administration & dosage Bacteriuria/microbiology Biological Products/administration & dosage Carboxylic Acids/administration & dosage Clavulanic Acid Clinical Trials as Topic Drug Combinations Enterobacteriaceae/drug effects Enterobacteriaceae Infections/drug therapy,microbiology Enzyme Inhibitors/administration & dosage Humans Penicillin Resistance Staphylococcal Infections/drug therapy,microbiology Staphylococcus aureus/drug effects Streptomyces Tablets Urinary Tract Infections/drug therapy beta-Lactamase Inhibitors beta-Lactams/administration & dosage
Chemicals
Biological Products Carboxylic Acids Drug Combinations Enzyme Inhibitors Tablets beta-Lactamase Inhibitors beta-Lactams Clavulanic Acid Amoxicillin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ball A P
Geddes A M
Davey P G
Farrell I D
Brookes G R
Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
0140-6736
DOI
10.1016/s0140-6736(80)91118-6
Published
1980-03-22
Pages
620-3
Language
English
Region
England
NLM ID
2985213R
Subset
IM
External Links
PubMed source DOI: 10.1016/s0140-6736(80)91118-6 View journal details
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