Recombinant antibodies possessing novel effector functions.

Nature ·Vol. 312 ·No. 5995 ·1984-00-00 ·Pages 604-8

Neuberger MS, Williams GT, Fox RO

Abstract

The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.

MeSH Terms

Animals Antibodies, Monoclonal/genetics Antigen-Antibody Complex Cell Line Chimera Cloning, Molecular DNA Restriction Enzymes Disulfides Genes Haptens Hybridomas/immunology Immunoglobulin Fab Fragments/genetics Lymphocytes/immunology Mice Micrococcal Nuclease/metabolism Oncogenes Plasmacytoma/immunology Plasmids Staphylococcus aureus/enzymology Transfection

Chemicals

Antibodies, Monoclonal Antigen-Antibody Complex Disulfides Haptens Immunoglobulin Fab Fragments DNA Restriction Enzymes Micrococcal Nuclease

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Neuberger M S

Williams G T

Fox R O

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/312604a0

Published

1984-00-00

Pages

604-8

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/312604a0 View journal details

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