Interaction of cardiac glycosides with (Na+ + K+)-activated ATPase. A biochemical link to digitalis-induced inotropy.

Adenosine Triphosphate/metabolism Animals Cardiac Glycosides/metabolism,pharmacology Digitalis Humans Kinetics Ligands Magnesium/pharmacology Myocardial Contraction/drug effects Ouabain/metabolism,pharmacology Plants, Medicinal Plants, Toxic Potassium/pharmacology Protein Conformation Receptors, Drug/analysis Sodium/metabolism Sodium-Potassium-Exchanging ATPase/analysis,metabolism Vanadates Vanadium/metabolism

Cardiac Glycosides Ligands Receptors, Drug cardiac glycoside receptors Vanadium Vanadates Ouabain Adenosine Triphosphate Sodium Sodium-Potassium-Exchanging ATPase Magnesium Potassium