Epidermal growth factor receptors in human breast cancer.

Breast cancer research and treatment ·Vol. 4 ·No. 3 ·1984-00-00 ·Pages 189-93

Pérez R, Pascual M, Macías A, Lage A

Abstract

The capacity for specific binding of 125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demonstrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

MeSH Terms

Animals Breast Neoplasms/metabolism Cell Membrane/metabolism Epidermal Growth Factor/metabolism ErbB Receptors Female Humans Kinetics Male Mice Placenta/metabolism Pregnancy Receptors, Cell Surface/isolation & purification,metabolism

Chemicals

Receptors, Cell Surface Epidermal Growth Factor ErbB Receptors

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Pérez R

Pascual M

Macías A

Lage A

References (18)

18 references, click to expand

MSA and EGF receptors on sarcoma virus transformed cells and human fibrosarcoma cells in culture.
Nature. 1977 Jun 9;267(5611):526-8 PMID: 195218
Standards for the assessment of estrogen receptors in human breast cancer. Report of a workshop on September 29, 1972, at the Antoni van Leeuwenhoek-Huis, Amsterdam.
Eur J Cancer. 1973 May;9(5):379-81 PMID: 4355727
Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture.
Cancer Res. 1982 Nov;42(11):4394-8 PMID: 6290036
The prognostic value of estrogen receptor determinations in patients with primary breast cancer: an update.
Cancer. 1980 Dec 15;46(12 Suppl):2794-6 PMID: 7448723
Growth factors from murine sarcoma virus-transformed cells.
Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5 PMID: 211512
Factors associated with prognosis in human breast cancer. IV. Progesterone receptors and clinical factors.
Neoplasma. 1983;30(5):593-601 PMID: 6656963
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.
J Biol Chem. 1972 Dec 10;247(23):7609-11 PMID: 4636326
Factors associated with prognosis in human breast cancer. III. Estradiol receptors and short term relapse.
Neoplasma. 1983;30(5):589-92 PMID: 6656962
Stimulation of mammary carcinoma cell proliferation by epithelial growth factor in vitro.
Cancer Res. 1969 Jul;29(7):1457-8 PMID: 5799163
Relationship of presence of progesterone receptors to prognosis in early breast cancer.
Cancer Res. 1980 Sep;40(9):3357-60 PMID: 7427948
Preparation of iodine-131 labelled human growth hormone of high specific activity.
Nature. 1962 May 5;194:495-6 PMID: 14450081
Evidence that hamster fibroblasts tumors emerge in nude mice through the process of two in vivo selections leading to growth factor "relaxation" and to immune resistance.
Int J Cancer. 1982 Mar 15;29(3):309-14 PMID: 7068279
Emergence of hamster fibroblast tumors in nude mice--evidence for in vivo selection leading to loss of growth factor requirement.
J Cell Physiol. 1981 Dec;109(3):387-96 PMID: 7320057
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues.
Arch Biochem Biophys. 1974 Oct;164(2):518-26 PMID: 4376663
Epidermal growth factor requirement for development of cultured mammary gland.
Nature. 1980 May 22;285(5762):250-2 PMID: 6966378
Epidermal growth factor stimulation of human breast cancer cells in culture.
Cancer Res. 1980 Jul;40(7):2361-6 PMID: 6966967
Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer.
Cancer Res. 1977 Dec;37(12):4669-71 PMID: 922747
Prognostic value of estrogen receptors in primary breast cancer.
Cancer. 1979 Aug;44(2):671-5 PMID: 476576

Article Info

Journal

Breast cancer research and treatment

Abbr.

Breast Cancer Res Treat

ISSN

0167-6806

DOI

10.1007/BF01806484

Published

1984-00-00

Pages

189-93

Language

English

Region

Netherlands

NLM ID

8111104

Subset

External Links

PubMed source DOI: 10.1007/BF01806484 View journal details

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