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PMID: 6086963 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Detection of the v-abl gene product at cell-substratum contact sites in Abelson murine leukemia virus-transformed fibroblasts.

Journal of virology ·Vol. 51 ·No. 2 ·1984-08-00 ·Pages 547-52

Rohrschneider LR, Najita LM

Abstract

Monoclonal antibodies to the p15 and p12 gag proteins were used to detect the P120gag-abl transforming protein of Abelson murine leukemia virus in nonproductively transformed normal rat kidney fibroblast cells. The results demonstrate that, in addition to the prominent plasma membrane location, P120gag-abl was associated with points of adhesion between the cell and the substratum. The localization of P120gag-abl was qualitatively similar to that reported for pp60src in the same normal rat kidney fibroblast cells and suggests that these transforming proteins may share some common transformation features.

MeSH Terms
Abelson murine leukemia virus/genetics Animals Antigens, Viral/genetics Cell Line Cell Transformation, Neoplastic Fibroblasts/physiology Gene Products, gag Genes Genes, Viral Kidney Leukemia Virus, Murine/genetics Rats Viral Proteins/genetics
Chemicals
Antigens, Viral Gene Products, gag Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rohrschneider L R
Najita L M
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23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.51.2.547-552.1984
Published
1984-08-00
Pages
547-52
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254471
Subset
IM
Grants
NCI NIH HHS · CA 20551 · United States
NCI NIH HHS · CA 28151 · United States
External Links
PubMed source DOI: 10.1128/JVI.51.2.547-552.1984 PMC Full Text View journal details
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