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PMID: 6085198 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

New poliovirus vaccines: a molecular approach.

Vaccine ·Vol. 2 ·No. 3 ·1984-09-00 ·Pages 177-84

Almond JW, Stanway G, Cann AJ, Westrop GD, Evans DM, Ferguson M, Minor PD, Spitz M, Schild GC

Abstract

This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed.

MeSH Terms

Amino Acid Sequence Animals Antibodies, Monoclonal Base Sequence Epitopes Mutation Oligopeptides Poliovirus/immunology Poliovirus Vaccine, Inactivated Poliovirus Vaccine, Oral Protein Conformation Rabbits Vaccines, Attenuated

Chemicals

Antibodies, Monoclonal Epitopes Oligopeptides Poliovirus Vaccine, Inactivated Poliovirus Vaccine, Oral Vaccines, Attenuated

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Almond J W

Stanway G

Cann A J

Westrop G D

Evans D M

Ferguson M

Minor P D

Spitz M

Schild G C

Article Info

Journal

Vaccine

Abbr.

Vaccine

ISSN

0264-410X

DOI

10.1016/0264-410x(84)90081-1

Published

1984-09-00

Pages

177-84

Language

English

Region

Netherlands

NLM ID

8406899

Subset

External Links

PubMed source DOI: 10.1016/0264-410x(84)90081-1 View journal details

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New poliovirus vaccines: a molecular approach.

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