Efficiency of the first component of complement (C'1) in the hemolytic reaction.

Science (New York, N.Y.) ·Vol. 158 ·No. 3808 ·1967-12-22 ·Pages 1590-2

Colten HR, Borsos T, Rapp HJ

Abstract

With the use of the first component of guinea pig complement (C'1) labeled in vivo with (14)C-amino acids, we have obtained evidence that, under the conditions required for the assay of C'1, each molecule of C'1 capable of interaction with cell surface antigen-antibody complexes is capable of initiating the reaction sequence that leads to lysis of the cell.

MeSH Terms

Animals Antigen-Antibody Reactions Binding Sites Carbon Isotopes Centrifugation, Density Gradient Complement System Proteins Guinea Pigs Hemolysis Humans Spectrophotometry

Chemicals

Carbon Isotopes Complement System Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Colten H R

Borsos T

Rapp H J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.158.3808.1590

Published

1967-12-22

Pages

1590-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.158.3808.1590 View journal details

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Efficiency of the first component of complement (C'1) in the hemolytic reaction.

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