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PMID: 6051796 Published · ppublish English Journal Article

Potassium transport and nucleoside metabolism in human red cells.

The Journal of physiology ·Vol. 191 ·No. 3 ·1967-08-00 ·Pages 633-52

Whittam R, Wiley JS

Abstract

1. A study has been made of active cation transport in relation to the metabolism of nucleosides and deoxynucleosides in human red blood cells.2. Lactate production from inosine depended on the cellular inorganic phosphate available for phosphorolysis and was raised to some 4 times the normal rate from glucose. Inosine inhibited glucose metabolism according to the amount of glucose-6-phosphate produced. Guanosine behaved similarly, but glucose-6-phosphate was not formed from adenosine, deoxyinosine and deoxyguanosine.3. Glucose metabolism was related to the ATP content of the cells, which was raised by incubation with adenosine, or with inosine plus adenine.4. Adenosine and deoxyadenosine raised the potassium influx above the values found with inosine and deoxyinosine under conditions when the lactate production was constant. Active potassium influx was correlated with the ATP concentration in the cells, but independent of the lactate production when the latter was raised above normal.

MeSH Terms
Adenosine Triphosphate/analysis,biosynthesis Biological Transport, Active Erythrocytes/metabolism Glucose/metabolism Humans Lactates/biosynthesis Male Nucleosides/metabolism Potassium/metabolism
Chemicals
Lactates Nucleosides Adenosine Triphosphate Glucose Potassium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Whittam R
Wiley J S
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50 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1967.sp008272
Published
1967-08-00
Pages
633-52
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1365496
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1967.sp008272 PMC Full Text View journal details
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