Release of slow-reacting substance of anaphylaxis in the rat: polymorphonuclear leukocyte.

Science (New York, N.Y.) ·Vol. 157 ·No. 3786 ·1967-07-21 ·Pages 318-9

Orange RP, Valentine MD, Austen KF

Abstract

The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slow-reacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.

MeSH Terms

Anaphylaxis/physiopathology Animals Antigens/pharmacology Complement System Proteins Inflammation/physiopathology Leukopenia/chemically induced Male Mast Cells Mechlorethamine Neutrophils/physiopathology Peritoneal Cavity Rats SRS-A/physiology Snakes Venoms

Chemicals

Antigens SRS-A Venoms Mechlorethamine Complement System Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Orange R P

Valentine M D

Austen K F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.157.3786.318

Published

1967-07-21

Pages

318-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.157.3786.318 View journal details

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Release of slow-reacting substance of anaphylaxis in the rat: polymorphonuclear leukocyte.

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