Potency difference between the zwitterion form and the cation forms of tetrodotoxin.

Science (New York, N.Y.) ·Vol. 156 ·No. 3782 ·1967-06-23 ·Pages 1625-7

Camougis G, Takman BH, Tasse JR

Abstract

Tetrodotoxin can exist as a zwitterion or two different cations in aqueous solutions. The cation forms are more potent in nerve block. Thus the lactone-hemilactal configuration of tetrodotoxin influences potency. Electrostatic attraction, hydrogen bonding, and intermolecular hemilactal formation are possible mechanisms of interaction with membrane receptors.

MeSH Terms

Action Potentials/drug effects Animals Anura Chemical Phenomena Chemistry, Physical Hydrogen-Ion Concentration In Vitro Techniques Ions Membranes Sciatic Nerve/physiology Solutions Tetrodotoxin Toxins, Biological/pharmacology

Chemicals

Ions Solutions Toxins, Biological Tetrodotoxin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Camougis G

Takman B H

Tasse J R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.156.3782.1625

Published

1967-06-23

Pages

1625-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.156.3782.1625 View journal details

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Potency difference between the zwitterion form and the cation forms of tetrodotoxin.

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