The volume of vascular compartment in rat hind limb muscles.
1. A non-recirculatory perfusion system has been developed suitable for the perfusion of the hind limbs of small experimental animals.2. By means of it a solution of T. 1824-labelled serum albumin has been introduced into the vascular compartment of the hind limbs of female rats under isogravimetric conditions. Excision and analysis of certain muscles has been used to provide information concerning the percentage distribution of the labelled albumin within these muscles.3. Experiments have been carried out in vivo employing [(131)I]labelled serum albumin and [(51)Cr]labelled erythrocytes in order to compare the vascular volumes determined under in vivo conditions and in perfusions, and to estimate the capillary haematocrit in vivo.4. The physiological validity of the methods used and the results obtained has been discussed.
18 references, click to expand
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Percentage of intercellular medium in human erythrocytes centrifuged from albumin and other media.J Physiol. 1959 Mar 12;145(3):658-66 PMID: 13642328
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Oxygen consumption of soleus muscles from normal, vitamin E-supplemented and vitamin E-deficient guinea pigs during rest and stimulation.Metabolism. 1963 Jun;12:570-5 PMID: 13968423
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Vascular-extravascular exchange of II31 plasma proteins in the rat.Am J Physiol. 1959 Aug;197:423-31 PMID: 13816325
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Change in capillary permeability during hypoxemic perfusion of rat hindlegs.Am J Physiol. 1954 Nov;179(2):216-20 PMID: 13218146
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A METHOD FOR EXTRACTION OF EVANS BLUE FROM PLASMA AND TISSUES.Proc Soc Exp Biol Med. 1964 May;116:220-2 PMID: 14200114
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Effect of pentobarbital anesthesia on the blood values of rat organs and tissues.Am J Physiol. 1957 Feb;188(2):403-8 PMID: 13411224
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Volume of interfibre spaces in frog muscle and the calculation of concentrations in the fibre water.J Physiol. 1941 Jun 30;99(4):401-14 PMID: 16995261
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Some observations on impurities present in samples of Evan's blue (T 1824) and their influence on blood-volume determinations effected by the dye method.J Physiol. 1954 Jan;123(1):16-21 PMID: 13131243
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Measurement of extracellular fluid volume using 131-I labelled inulin.Clin Chim Acta. 1963 May;8:333-42 PMID: 13945448
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Body size and tissue respiration.Biochim Biophys Acta. 1950 Jan;4(1-3):249-69 PMID: 15403932
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A method for testing the purity of commercial samples of T 1824 with observations on the amounts of colored impurities present and the errors in plasma volume estimation caused by them.J Physiol. 1949 Aug;109(1-2):170-6 PMID: 15394317
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On the physical equilibrium of small blood vessels.Am J Physiol. 1951 Feb;164(2):319-29 PMID: 14810937
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