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PMID: 5942999 Published · ppublish English Journal Article

The inhibitory innervation of the taenia of the guinea-pig caecum.

The Journal of physiology ·Vol. 182 ·No. 3 ·1966-02-00 ·Pages 504-26

Burnstock G, Campbell G, Rand MJ

Abstract

1. The inhibitory innervation of the taenia of the guinea-pig caecum has been studied, after blocking the responses to stimulation of excitatory cholinergic nerves with atropine.2. Stimulation of the perivascular nerves supplying the taenia caused relaxations. These nerves had properties which were typical of sympathetic post-ganglionic adrenergic nerves. The relaxations caused by stimulation were maximal at frequencies of stimulation above 30 pulses/sec and they were abolished by bretylium, guanethidine and 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP).3. The taenia is also innervated by intramural inhibitory nerves with their cell bodies in Auerbach's plexus. These nerves can be excited by electrical stimulation of the taenia or by the application of ganglion-stimulating drugs.4. The intramural inhibitory nerves have different properties from sympathetic adrenergic nerves. Relaxations in response to stimulation were maximal with frequencies of stimulation of about 5 pulses/sec and they were not blocked by bretylium, guanethidine or DMPP.5. Preganglionic cholinergic fibres in the caecal wall make synaptic connexions with the intramural inhibitory neurones.6. The role of the intramural inhibitory neurones in intestinal activity and their possible connexions with the central nervous system have been discussed.

MeSH Terms
Anesthetics, Local/pharmacology Animals Atropine/pharmacology Bretylium Compounds/pharmacology Cecum Electric Stimulation Guanethidine/pharmacology Guinea Pigs In Vitro Techniques Muscle, Smooth/innervation Myenteric Plexus/drug effects Neuromuscular Junction/drug effects,physiology Nicotine/pharmacology Pentolinium Tartrate/pharmacology Piperazines/pharmacology Procaine/pharmacology
Chemicals
Anesthetics, Local Bretylium Compounds Piperazines Procaine Nicotine Atropine Pentolinium Tartrate Guanethidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Burnstock G
Campbell G
Rand M J
References (43)
43 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1966.sp007834
Published
1966-02-00
Pages
504-26
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1357484
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1966.sp007834 PMC Full Text View journal details
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