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PMID: 5914248 Published · ppublish English Journal Article

Pharmacological studies on feline Betz cells.

The Journal of physiology ·Vol. 186 ·No. 1 ·1966-09-00 ·Pages 121-38

Crawford JM, Curtis DR

Abstract

1. A study has been made of the sensitivity of single neurones in the pericruciate cortex of anaesthetized and unanaesthetized cats to cholinomimetics administered electrophoretically from multibarrel micropipettes.2. A high proportion of deep pyramidal cells, including Betz cells, were excited by these substances, and the receptors involved have muscarinic characteristics.3. Atropine specifically reduced the sensitivity of cortical neurones to acetylcholine, but no such action could be demonstrated for dihydro-beta-erythroidine, gallamine or general anaesthetics.4. The significance of these results is discussed in relation to the possible synaptic or non-synaptic action of acetylcholine upon cortical neurones.

MeSH Terms
Animals Atropine/pharmacology Cats Cerebral Cortex/drug effects Neurons/drug effects Pyramidal Tracts/drug effects Sensory Receptor Cells/drug effects Synapses/drug effects
Chemicals
Atropine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crawford J M
Curtis D R
References (27)
27 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1966.sp008024
Published
1966-09-00
Pages
121-38
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1395892
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1966.sp008024 PMC Full Text View journal details
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