Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.

Science (New York, N.Y.) ·Vol. 151 ·No. 3707 ·1966-01-14 ·Pages 209-10

Gabbay KH, Merola LO, Field RA

Abstract

Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.

MeSH Terms

Animals Diabetes Mellitus, Experimental/metabolism Diabetic Neuropathies/etiology Fructose/metabolism Glucose/metabolism In Vitro Techniques Inositol/metabolism Peripheral Nerves/metabolism Rats Sorbitol/metabolism Spinal Cord/metabolism

Chemicals

Fructose Inositol Sorbitol Glucose

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gabbay K H

Merola L O

Field R A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.151.3707.209

Published

1966-01-14

Pages

209-10

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.151.3707.209 View journal details

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Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.

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