The state of hemoglobin in sickled erythrocytes.

The Journal of experimental medicine ·Vol. 123 ·No. 2 ·1966-02-01 ·Pages 341-6

Stetson CA

Abstract

Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably for the disease itself.

MeSH Terms

Anemia, Sickle Cell/physiopathology Erythrocytes Hemoglobins, Abnormal In Vitro Techniques Microscopy, Electron X-Ray Diffraction

Chemicals

Hemoglobins, Abnormal

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Stetson C A

References (9)

9 references, click to expand

State of haemoglobin in sickle-cell anaemia.
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X-ray and solubility studies of the haemoglobin of sickle-cell anaemia patients.
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[Microscopic structure of erythrocytes with abnormal hemoglobin].
Rev Hematol. 1952;7(4):567-74 PMID: 13048114
A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin.
Nature. 1956 Oct 13;178(4537):792-4 PMID: 13369537
Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.
Nature. 1957 Aug 17;180(4581):326-8 PMID: 13464827
[Sickling of erythrocytes studied with polarized light & electron microscopes. II. Erythrocyte internal structure; comparison with intra-erythrocytic crystals].
Rev Hematol. 1958 Apr-Jun;13(2):249-70 PMID: 13568373
The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.
J Cell Biol. 1963 Apr;17:208-12 PMID: 13986422
Sickle cell anemia a molecular disease.
Science. 1949 Nov 25;110(2865):543-8 PMID: 15395398
A simplified technique for a large scale crystallization of human oxyhemoglobin; isomorphous transformations of hemoglobin and myoglobin in the crystalline state.
Arch Biochem. 1949 Mar;21(1):224-32 PMID: 18124508

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.123.2.341

Published

1966-02-01

Pages

341-6

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138140

Subset

External Links

PubMed source DOI: 10.1084/jem.123.2.341 PMC Full Text View journal details

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