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PMID: 5849238 Published · ppublish English Journal Article

Genetic control of combining sites of insulin antibodies produced by guinea pigs.

The Journal of experimental medicine ·Vol. 122 ·No. 4 ·1965-10-01 ·Pages 771-84

Arquilla ER, Finn J

Abstract

1. Genetic factors control the configuration of combining sites of guinea pig insulin antibodies. 2. It is possible that the configuration of the combining sites of guinea pig insulin antibodies is controlled by more than one gene and not by multiple alleles at a given gene locus.

MeSH Terms
Animals Genetics Guinea Pigs In Vitro Techniques Insulin Antibodies
Chemicals
Insulin Antibodies
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Arquilla E R
Finn J
References (8)
8 references, click to expand
  1. The production and identification of antibodies to insulin and their use in assaying insulin.
    J Clin Invest. 1956 May;35(5):458-66 PMID: 13319479
  2. GENETIC DIFFERENCES IN ANTIBODY PRODUCTION TO DETERMINANT GROUPS ON INSULIN.
    Science. 1963 Oct 18;142(3590):400-1 PMID: 14061195
  3. BASIS FOR THE ANTIGENICITY OF HAPTEN-POLY-L-LYSINE CONJUGATES IN RANDOM-BRED GUINEA PIGS.
    Nature. 1963 Nov 9;200:544-6 PMID: 14082222
  4. The genetic control of response to antigenic stimuli.
    J Immunol. 1954 Jan;72(1):52-65 PMID: 13118192
  5. CORROBORATION OF RECENT MODELS OF THE GAMMA-G IMMUNOGLOBULIN MOLECULE.
    J Exp Med. 1965 Mar 1;121:373-93 PMID: 14270239
  6. The contribution of sialic acid to the surface charge of the erythrocyte.
    J Biol Chem. 1962 Jun;237:1992-2000 PMID: 13891108
  7. STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.
    J Exp Med. 1963 Dec 1;118:953-7 PMID: 14112274
  8. INSULIN ANTIBODY VARIATIONS IN RABBITS AND GUINEA PIGS AND MULTIPLE ANTIGENIC DETERMINANTS ON INSULIN.
    J Exp Med. 1963 Jul 1;118(1):55-71 PMID: 19867233
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.122.4.771
Published
1965-10-01
Pages
771-84
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138094
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.122.4.771 PMC Full Text View journal details
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