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PMID: 5838073 Published · ppublish English Journal Article

Distribution and metabolism of DL-3,4-dihydroxy[2-14C]-phenylalanine in rat tissues.

The Biochemical journal ·Vol. 92 ·No. 2 ·1964-08-00 ·Pages 300-8

Gey KF, Pletscher A

Abstract

暂无摘要

MeSH Terms
Adrenal Glands/metabolism Animals Aorta/metabolism Blood Brain/metabolism Carbonates/metabolism Chromatography, Paper Dihydroxyphenylalanine/metabolism Dopamine/metabolism Intestine, Small/metabolism Kidney/metabolism Liver/metabolism Muscles/metabolism Myocardium/metabolism Phenols/metabolism Rats Skin/metabolism Urine
Chemicals
Carbonates Phenols Dihydroxyphenylalanine Dopamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gey K F
Pletscher A
References (43)
43 references, click to expand
  1. The development of current concepts of catecholamine formation.
    Pharmacol Rev. 1959 Jun;11(2, Part 2):307-16 PMID: 13667411
  2. The metabolism of 3, 4-dihydroxyphenylalanine.
    J Biol Chem. 1957 May;226(1):255-66 PMID: 13428759
  3. Metabolism of epinephrine and other sympathomimetic amines.
    Physiol Rev. 1959 Oct;39:751-76 PMID: 13795318
  4. The activity of l(-)-dopa decarboxylase.
    J Physiol. 1942 Nov 30;101(3):337-49 PMID: 16991567
  5. Biosynthesis of adrenaline and noradrenaline.
    Pharmacol Rev. 1959 Jun;11(2, Part 2):350-7 PMID: 13667414
  6. The scope of the transamination reaction in animal tissues.
    J Biol Chem. 1950 Nov;187(1):439-52 PMID: 14794729
  7. Distribution of catechol compounds in human brain.
    Biochim Biophys Acta. 1959 Apr;32:586-7 PMID: 14441532
  8. [Monoamine oxidase inhibitors].
    Fortschr Arzneimittelforsch. 1960;2:417-590 PMID: 13736336
  9. The physiological disposition of H3-epinephrine and its metabolite metanephrine.
    J Pharmacol Exp Ther. 1959 Dec;127:251-6 PMID: 13795315
  10. Excretion of 3,4-dihydroxyphenylalanine in urine.
    Biochim Biophys Acta. 1961 Nov 11;53:603-5 PMID: 13898043
  11. Catecholamine formation in intact tissues.
    Pharmacol Rev. 1959 Jun;11(2, Part 2):358-60 PMID: 13667415
  12. Nonspecificity of tyrosine transaminase: an explanation for the simultaneous induction of tyrosine, phenylalanine, and tryptophan transaminase activities in rat liver.
    Biochem Biophys Res Commun. 1962 Aug 7;8:352-6 PMID: 14450759
  13. [Presence of dihydroxyphenylalanine in the central nervous system of the rabbit].
    C R Seances Soc Biol Fil. 1961;155:420-2 PMID: 13724351
  14. Topographical differences in the cerebral metabolism of DL-2-14C-3,4-dihydroxphenylalanine.
    Experientia. 1962 Nov 15;18:512-3 PMID: 13944046
  15. Enzymes and their substrates in the adrenal gland of the ox.
    Br J Pharmacol Chemother. 1951 Jun;6(2):318-24 PMID: 14848462
  16. Enzymatic O-methylation of epinephrine and other catechols.
    J Biol Chem. 1958 Sep;233(3):702-5 PMID: 13575440
  17. Occurrence, isolation and identification of 3-methoxy-4-hydroxyphenylalanine.
    Clin Chim Acta. 1961 Jul;6:526-30 PMID: 13917982
  18. ORIGIN OF NOREPINEPHRINE IN THE HEART.
    Nature. 1963 Sep 28;199:1289 PMID: 14074596
  19. A method for the fluorimetric determination of adrenaline and noradrenaline in tissues.
    Acta Physiol Scand. 1958 Dec 15;44(3-4):273-92 PMID: 13617023
  20. Catechol compounds in rat tissues and in brains of different animals.
    Nature. 1957 Aug 3;180(4579):244-5 PMID: 13451690
  21. The action of antidecarboxylases on the conversion of 3,4-dihydroxyphenylalanine to dopamine in vivo.
    Arch Biochem Biophys. 1961 May;93:338-43 PMID: 13726974
  22. Metabolism of 3-hydroxy- and 3,4-dihydroxyphenylpyruvic acids in vivo.
    J Pharmacol Exp Ther. 1961 Mar;131:294-307 PMID: 13736556
  23. [Decarboxylation of DOPA by the myocardium of guinea pigs].
    Klin Wochenschr. 1962 Sep 1;40:911-3 PMID: 14476936
  24. A method for the determination of some amino acid decarboxylases.
    J Biol Chem. 1960 Jan;235:124-7 PMID: 13814522
  25. Metabolism of administered and drug-released norepinephrine-7-H3 in the rat.
    J Pharmacol Exp Ther. 1963 May;140:207-16 PMID: 14034693
  26. Effect of L-DOPA and N-methyl-N-benzyl-2-propynylamine. HC1 on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain.
    Biochem Pharmacol. 1961 Aug;7:181-6 PMID: 13785077
  27. Conversion of tryptopan to 5-hydroxytryptophan by phenylalanine hydroxylase.
    Biochem Biophys Res Commun. 1961 Oct 23;6:20-3 PMID: 14491500
  28. The enzymatic hydroxylation of tryptophan.
    Biochem Biophys Res Commun. 1961 Jun 2;5:94-8 PMID: 13701596
  29. A rapid method for the determination of dihydroxyphenylalanine decarboxylase in animal tissues.
    J Biol Chem. 1953 Oct;204(2):587-91 PMID: 13117832
  30. Dopa uptake and catecholamine content in heart and spleen.
    Am J Physiol. 1961 Oct;201:673-6 PMID: 14005571
  31. Aromatic L-amino acid decarboxylase.
    J Biol Chem. 1962 Jan;237:89-93 PMID: 14466899
  32. A chromatographic investigation of pancreatic ribonuclease.
    J Biol Chem. 1953 Feb;200(2):493-506 PMID: 13034806
  33. Transamination of aromatic amino-acids in nervous tissue.
    Nature. 1962 Nov 10;196:577-8 PMID: 13951615
  34. Phenylalanine and tyrosine in the adrenal medulla.
    Acta Physiol Scand. 1961 May;52:49-52 PMID: 13710774
  35. Kinetic and substrate specificity study of tyrosine-alpha-ketoglutaric acid transaminase.
    J Biol Chem. 1956 Sep;222(1):63-71 PMID: 13366979
  36. Localizing tritiated norepinephrine in sympathetic axons by electron microscopic autoradiography.
    Science. 1962 Oct 19;138(3538):440-2 PMID: 14001559
  37. The fate of H3-norepinephrine in animals.
    J Pharmacol Exp Ther. 1961 May;132:193-201 PMID: 13784801
  38. Metabolism of radioactive beta-(3, 4-dihydroxyphenyl)-alanine-alpha-C14 in the albino rat.
    Can J Biochem Physiol. 1955 Nov;33(6):1055-61 PMID: 13270133
  39. Role of L-DOPA decarboxylase in the biosynthesis of catecholamines in nervous tissue and the adrenal medulla.
    Pharmacol Rev. 1959 Jun;11(2, Part 2):317-29 PMID: 13667412
  40. Distribution and fate of dihydroxyphenylalanine-2-14C (DOPA) in mice.
    Biochem Pharmacol. 1963 Mar;12:265-9 PMID: 13974812
  41. NOREPINEPHRINE AND 3,4DIHYDROXYPHENETHYLAMINE TURNOVER IN GUINEA PIG BRAIN IN VIVO.
    Science. 1963 Oct 18;142(3590):394-6 PMID: 14056708
  42. Studies on aromatic amino acid uptake by rat brain in vivo. Uptake of phenylalanine and of tryptophan; inhibition and stereoselectivity in the uptake of tyrosine by brain and muscle.
    J Biol Chem. 1962 Mar;237:803-6 PMID: 13903058
  43. Properties of a carrier system to transport L-dopa into brain slices.
    Nature. 1963 Apr 13;198:191-2 PMID: 14002670
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj0920300
Published
1964-08-00
Pages
300-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1205994
Subset
IM
External Links
PubMed source DOI: 10.1042/bj0920300 PMC Full Text View journal details
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