Protein synthesis by ribosomes from heart muscle: effect of insulin and diabetes.

Science (New York, N.Y.) ·Vol. 149 ·No. 3688 ·1965-09-03 ·Pages 1102-3

Rampersad OR, Wool IG

Abstract

Incorporation of phenylalanine into protein by ribosomes from the heart muscle of rats is decreased when the ribosomes are from alloxan-diabetic animals. Protein synthesis is increased when the ribosomes are obtained from nondiabetic animals I hour after treatment with insulin. The change due to insulin appears to be an alteration in the function of the ribosome.

MeSH Terms

Animals Diabetes Mellitus, Experimental/metabolism In Vitro Techniques Insulin/pharmacology Myocardium/metabolism Phenylalanine/metabolism Protein Biosynthesis RNA, Transfer Rats Ribosomes

Chemicals

Insulin Phenylalanine RNA, Transfer

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rampersad O R

Wool I G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.149.3688.1102

Published

1965-09-03

Pages

1102-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.149.3688.1102 View journal details

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Protein synthesis by ribosomes from heart muscle: effect of insulin and diabetes.

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