Turnover of ribosomal RNA in rat liver.

Science (New York, N.Y.) ·Vol. 149 ·No. 3688 ·1965-09-03 ·Pages 1093-5

Loeb JN, Howell RR, Tomkins GM

Abstract

After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about S days. The possible significance of this result is discussed with regard to control of protein synthesis.

MeSH Terms

Animals Carbon Isotopes Liver/cytology,metabolism Orotic Acid/metabolism RNA/biosynthesis Radiometry Rats

Chemicals

Carbon Isotopes Orotic Acid RNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Loeb J N

Howell R R

Tomkins G M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.149.3688.1093

Published

1965-09-03

Pages

1093-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.149.3688.1093 View journal details

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Turnover of ribosomal RNA in rat liver.

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