Androgen accumulation andbinding to macromolecules in seminal vesicles: inhibition cyproterone.

Science (New York, N.Y.) ·Vol. 166 ·No. 3902 ·1969-10-10 ·Pages 233-5

Stern JM, Eisenfeld AJ

Abstract

Cyproterone reduces the accumulation of testosterone and dihydrotestosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.

MeSH Terms

Animals Binding Sites Castration Injections, Intravenous Macromolecular Substances Male Rabbits Seminal Vesicles/metabolism Steroids/chemical synthesis Testosterone/antagonists & inhibitors,metabolism Tritium

Chemicals

Macromolecular Substances Steroids Tritium Testosterone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stern J M

Eisenfeld A J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.166.3902.233

Published

1969-10-10

Pages

233-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.166.3902.233 View journal details

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Androgen accumulation andbinding to macromolecules in seminal vesicles: inhibition cyproterone.

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