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PMID: 580732 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Bile acid conjugation in the chimpanzee: effective sulfation of lithocholic acid.

Archives of toxicology ·Vol. 40 ·No. 2 ·1978-04-27 ·Pages 109-18

Schwenk M, Hofmann AF, Carlson GL, Carter JA, Coulston F, Greim H

Abstract

To characterize the hepatic biotransformation in the chimpanzee of the primary bile acid chenodeoxycholic acid (chenic) and its major bacterial metabolite lithocholic acid (lithocholic) a mixture of trace amounts of 14C-lithocholic and 3H-chenic was injected intravenously into two animals with a bile fistula; the chemical form of radioactivity appearing in bile was inferred using thin layer chromatography. About 80% of chenic, and 70% of lithocholic was recovered in 90 min. Chenic was completely conjugated in bile, appearing predominantly as chenyltaurine (52%) and chenylglycine (37%). An unidentified conjugate (about 11%) was also found. Lithocholic was excreted completely as taurine and glycine conjugates, but the majority (63%) of conjugates was sulfated. Sulfation increased progressively with time, and lithocholylglycine was sulfated more than lithocholyltaurine. We conclude that the chimpanzee is similar to man in that the secondary bile acid lithocholic is efficiently sulfated. The chimpanzee thus differs from the baboon and rhesus monkey which sulfate lithocholic poorly. However, the chimpanzee differs from man and is similar to the baboon and rhesus monkey in showing preferential conjugation of bile acids with taurine. The results imply that hepatotoxicity caused by chenic, which is well documented in the rhesus monkey and baboon and has been related to defective lithocholic sulfation, should not occur in the chimpanzee.

MeSH Terms
Animals Bile/metabolism Biotransformation Chenodeoxycholic Acid/metabolism Glycine/metabolism Lithocholic Acid/metabolism Liver/metabolism Male Pan troglodytes/metabolism Taurine/metabolism Time Factors
Chemicals
Chenodeoxycholic Acid Taurine Lithocholic Acid Glycine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Schwenk M
Hofmann A F
Carlson G L
Carter J A
Coulston F
Greim H
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37 references, click to expand
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Article Info
Journal
Archives of toxicology
Abbr.
Arch Toxicol
ISSN
0340-5761
Published
1978-04-27
Pages
109-18
Language
English
Region
Germany
NLM ID
0417615
Subset
IM
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