Induction in vitro of microtubular crystals by vinca alkaloids.

Science (New York, N.Y.) ·Vol. 165 ·No. 3892 ·1969-08-01 ·Pages 495-6

Bensch KG, Marantz R, Wisniewski H, Shelanski M

Abstract

The addition of vinblastine or vincristine to solutions of pure microtubule protein or to supernatants from high-speed centrifugation of rabbit-brain homogenates results in the formation of a fine precipitate. Examination of this precipitate by electron microscopy reveals ordered structures with areas of ladder-like configuration.

MeSH Terms

Animals Brain Chemistry Chemical Precipitation Crystallization In Vitro Techniques Microscopy, Electron Proteins Rabbits Swine Vinblastine Vincristine

Chemicals

Proteins Vincristine Vinblastine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bensch K G

Marantz R

Wisniewski H

Shelanski M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.165.3892.495

Published

1969-08-01

Pages

495-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.165.3892.495 View journal details

Analysis Services

Induction in vitro of microtubular crystals by vinca alkaloids.

Contact

WeChat Official Account