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PMID: 5792911 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Effects of beta-adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects.

British medical journal ·Vol. 3 ·No. 5663 ·1969-07-19 ·Pages 143-5

Richardson PS, Sterling GM

Abstract

Ten normal and five asthmatic subjects were given intravenous injections of 10 ml. of 0.9% saline with and without 10 mg. of propranolol, and specific airway conductance was followed in a whole-body plethysmograph. Saline alone had no significant effect on conducatance in either group of subjects. Propranolol had no significant effect on conductance in normal subjects, but caused a mean fall of 34.9% in the asthmatics.

MeSH Terms
Asthma/drug therapy Humans Injections, Intravenous Lung/drug effects Plethysmography Propranolol/pharmacology Respiratory Physiological Phenomena Respiratory System/drug effects Sodium Chloride/pharmacology
Chemicals
Sodium Chloride Propranolol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Richardson P S
Sterling G M
References (12)
12 references, click to expand
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    N Engl J Med. 1966 Sep 15;275(11):580-4 PMID: 5920412
  2. Effect of propranolol on ventilatory function.
    Am J Cardiol. 1966 Sep;18(3):473-5 PMID: 5922891
  3. Variability of plethysmographic measurements of airways resistance in man.
    J Appl Physiol. 1967 Feb;22(2):383-9 PMID: 6017915
  4. Mechanism of bronchoconstriction caused by cigarette smoking.
    Br Med J. 1967 Jul 29;3(5560):275-7 PMID: 6028730
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    Br J Anaesth. 1967 Dec;39(12):919-26 PMID: 4866848
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    Clin Sci. 1968 Apr;34(2):277-85 PMID: 5653688
  7. Evidence for an adrenergic homeostatic bronchodilator reflex mechanism.
    Eur J Pharmacol. 1967 Dec;2(3):214-23 PMID: 5590346
  8. Treatment of hypertension with propranolol.
    Br Med J. 1969 Jan 4;1(5635):7-16 PMID: 5761914
  9. A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects.
    J Clin Invest. 1956 Mar;35(3):322-6 PMID: 13295396
  10. A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease.
    J Clin Invest. 1956 Mar;35(3):327-35 PMID: 13295397
  11. Acute effects of inhalation of cigarette smoke on airway conductance.
    J Appl Physiol. 1961 Jul;16:713-6 PMID: 13727341
  12. EFFECT OF A BETA-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS.
    Lancet. 1964 Nov 21;2(7369):1101-2 PMID: 14207902
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.3.5663.143
Published
1969-07-19
Pages
143-5
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1983961
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.3.5663.143 PMC Full Text
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