[Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)].

Polymorphismen und Defekte des Arzneimittelstoffwechesels als Ursache toxischer Reaktionen.

Arzneimittel-Forschung ·Vol. 27 ·No. 96 ·1977-00-00 ·Pages 1836-44

Dengler HJ, Eichelbaum M

Abstract

The influences of polymorphisms and pharmacokinetic defects of drug metabolism as causes of toxic drug reactions are presented. The different mechanisms of toxic side effects mediated by alterations of the metabolism and excretion of drugs are discussed.

MeSH Terms

Animals Antipyrine/adverse effects Cyclacillin/adverse effects Diazepam/adverse effects Drug-Related Side Effects and Adverse Reactions Humans Kidney Diseases/chemically induced Pharmacogenetics Phenylbutazone/adverse effects Polymorphism, Genetic Primidone/adverse effects Rats

Chemicals

Primidone Cyclacillin Phenylbutazone Diazepam Antipyrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Dengler H J

Eichelbaum M

Article Info

Journal

Arzneimittel-Forschung

Abbr.

Arzneimittelforschung

ISSN

0004-4172

Published

1977-00-00

Pages

1836-44

Language

ger

Region

Germany

NLM ID

0372660

Subset

External Links

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[Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)].

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