Significance of the changes in the circulating lymphoid cells in Hodgkin's disease.

British medical journal ·Vol. 2 ·No. 5655 ·1969-05-24 ·Pages 473-7

Cowther D, Fairley GH, Sewell RL

Abstract

The lymphoid cell population in the peripheral blood in Hodgkin's disease differs from normal blood in three ways. Firstly, the number of large lymphoid cells actively synthesizing deoxyribonucleic acid is increased; secondly, the number of medium-sized lymphoid cells with intensely basophilic cytoplasm is increased; and, thirdly, occasional plasma cells are seen. These changes are related to the activity but not to the stage of the disease.Similar changes are found under conditions of known antigenic challenge-that is, in infections, and after immunization, and in rheumatoid arthritis and systemic lupus erythematosus.

MeSH Terms

Arthritis, Rheumatoid/pathology Autoimmune Diseases Basophils DNA/biosynthesis Hodgkin Disease/blood Humans Immunization Infections/pathology Leukocyte Count Lupus Erythematosus, Systemic/pathology Lymphocytes/metabolism Lymphoid Tissue/cytology Plasma Cells

Chemicals

DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Cowther D

Fairley G H

Sewell R L

References (10)

10 references, click to expand

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Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis.
Proc Natl Acad Sci U S A. 1968 Jan;59(1):94-101 PMID: 5242134
Relation between Epstein-- Barr viral and cell membrane immunofluorescence in Burkitt tumor cells. II. Comparison of cells and sera from patients with Burkitt's lymphoma and infectious mononucleosis.
J Exp Med. 1968 Nov 1;128(5):1021-30 PMID: 4878907
Lymphoid cellular responses in the blood after immunization in man.
J Exp Med. 1969 May 1;129(5):849-69 PMID: 5778787
VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA.
Lancet. 1964 Mar 28;1(7335):702-3 PMID: 14107961
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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5655.473

Published

1969-05-24

Pages

473-7

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1983441

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5655.473 PMC Full Text

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Significance of the changes in the circulating lymphoid cells in Hodgkin's disease.

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