Adrenal tyrosine hydroxylase: compensatory increase in activity after chemical sympathectomy.

Science (New York, N.Y.) ·Vol. 163 ·No. 3866 ·1969-01-31 ·Pages 468-9

Mueller RA, Thoenen H, Axelrod J

Abstract

Destruction of peripheral sympathetic nerve endings with 6-hydroxydopamine causes a disappearance of cardiac tyrosine hydroxylase, accompanied by a twofold increase in adrenal tyrosine hydroxylase and a small increase in phenyl-ethanolanine-N-methyl transferase. No change in adrenal catecholamine content occurs under these conditions.

MeSH Terms

Adrenal Glands/drug effects,enzymology,innervation Animals Catecholamines/pharmacology Dopamine Epinephrine/biosynthesis Heart/drug effects,innervation Male Mixed Function Oxygenases/metabolism Myocardium/enzymology Nerve Endings/drug effects Norepinephrine/biosynthesis Phenethylamines/pharmacology Rats Sympathetic Nervous System/drug effects Transferases/metabolism Tyrosine

Chemicals

Catecholamines Phenethylamines Tyrosine Mixed Function Oxygenases Transferases Dopamine Norepinephrine Epinephrine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mueller R A

Thoenen H

Axelrod J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.163.3866.468

Published

1969-01-31

Pages

468-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.163.3866.468 View journal details

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Adrenal tyrosine hydroxylase: compensatory increase in activity after chemical sympathectomy.

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