Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes.

Science (New York, N.Y.) ·Vol. 159 ·No. 3822 ·1968-03-29 ·Pages 1469-70

Rubin E, Hutterer F, Lieber CS

Abstract

Rats were fed ethanol for 2 weeks along with diets either adequate or deficient in protein and choline, the latter intake being similar to that of many alcoholics. Hepatic lipids, smooth endoplasmic reticulum, and the activities of drug-metabolizing enzymes (aniline hydroxylase and nitroreductase) were increased with the adequate diet but more so with the deficient one. These results may explain the increased tolerance by alcoholics of drugs such as sedatives.

MeSH Terms

Alcoholism Aniline Compounds Animals Drug Tolerance Endoplasmic Reticulum/drug effects,enzymology Ethanol/pharmacology Humans Hypnotics and Sedatives Lipids/analysis Liver/analysis,cytology,drug effects,enzymology Male Microscopy, Electron Mixed Function Oxygenases/metabolism Oxidoreductases/metabolism Rats Triglycerides/analysis

Chemicals

Aniline Compounds Hypnotics and Sedatives Lipids Triglycerides Ethanol Mixed Function Oxygenases Oxidoreductases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rubin E

Hutterer F

Lieber C S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.159.3822.1469

Published

1968-03-29

Pages

1469-70

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.159.3822.1469 View journal details

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Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes.

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