Inactivating and mutagenic effects of 1-methyl-3-nitro-1-nitrosoguanidine on intracellular bacteriophage.

Journal of virology ·Vol. 2 ·No. 9 ·1968-09-00 ·Pages 901-4

Zampieri A, Greenberg J, Warren G

Abstract

1-Methyl-3-nitro-1-nitrosoguanidine (NG) was able to inactivate and mutate adsorbed but not free coliphage T2. Coliphage T4 was as sensitive to NG as T2. When treatment was delayed for 5 min or longer after adsorption of T2, the phage became increasingly refractory to NG inactivation.

MeSH Terms

Adsorption Coliphages/drug effects Guanidines/pharmacology Mutagens/pharmacology Mutation Nitroso Compounds/pharmacology

Chemicals

Guanidines Mutagens Nitroso Compounds

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Zampieri A

Greenberg J

Warren G

References (10)

10 references, click to expand

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EFFECT OF SOME RADIOMIMETIC AGENTS ON DEOXYRIBONUCLEIC ACID SYNTHESIS IN ESCHERICHIA COLI AND TRANSFORMATION IN BACILLUS SUBTILIS.
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Chemical modification of viral RNA. VI. The action of N-methyl-N'-nitro-N-nitrosoguanidine.
Proc Natl Acad Sci U S A. 1967 Jul;58(1):234-9 PMID: 5231604
Noninfectious bacteriophage produced by the action of mitomycin C.
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A new chemical mutagen for bacteria, 1-methyl-3-nitro-1-nitrosoguanidine.
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Effect of mitomycin C on the synthesis of bacterial and viral deoxyribonucleic acid.
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.2.9.901-904.1968

Published

1968-09-00

Pages

901-4

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375710

Subset

External Links

PubMed source DOI: 10.1128/JVI.2.9.901-904.1968 PMC Full Text View journal details

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Inactivating and mutagenic effects of 1-methyl-3-nitro-1-nitrosoguanidine on intracellular bacteriophage.

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