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PMID: 5701682 Published · ppublish English Journal Article

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Carbohydrate metabolism.

The Biochemical journal ·Vol. 110 ·No. 3 ·1968-12-00 ·Pages 521-7

Senior AE, Sherratt HS

Abstract

1. The effects of the hypoglycaemic compound, pent-4-enoic acid, and of four structurally related non-hypoglycaemic compounds (pent-2-enoic acid, pentanoic acid, cyclopropanecarboxylic acid and cyclobutanecarboxylic acid), on glycolysis, glucose oxidation and gluconeogenesis in some rat tissues were determined. 2. None of the compounds at low concentrations inhibited glycolysis by particle-free supernatant fractions from rat liver, skeletal muscle and intestinal mucosa, though there was inhibition by cyclopropanecarboxylic acid and cyclobutanecarboxylic acid at 3mm concentration. 3. Pent-4-enoic inhibited the oxidation of [1-(14)C]palmitate by rat liver slices, but did not increase the oxidation of [U-(14)C]glucose. 4. Pent-4-enoic acid (0.01mm) strongly inhibited gluconeogenesis by rat kidney slices from pyruvate or succinate, but none of the other compounds inhibited significantly at low concentrations. 5. There was also some inhibition of gluconeogenesis in kidney slices from rats injected with pent-4-enoic acid. 6. The mechanism of the hypoglycaemic effect of pent-4-enoic acid is discussed; it is suggested that there is an inhibition of fatty acid and ketone-body oxidation and of gluconeogenesis so that glucose reserves become exhausted, leading to hypoglycaemia. 7. The mechanism of the hypoglycaemic action of pent-4-enoic acid appears to be similar to that of hypoglycin.

MeSH Terms
Animals Carbon Isotopes Cell-Free System Cycloparaffins/pharmacology Cyclopropanes/pharmacology Depression, Chemical Fatty Acids/metabolism,pharmacology Gluconeogenesis/drug effects Glucose/metabolism Glycolysis/drug effects Hypoglycemic Agents/pharmacology In Vitro Techniques Intestinal Mucosa/metabolism Ketone Bodies/metabolism Kidney/metabolism Liver/metabolism Muscles/metabolism Rats Valerates/pharmacology
Chemicals
Carbon Isotopes Cycloparaffins Cyclopropanes Fatty Acids Hypoglycemic Agents Ketone Bodies Valerates Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Senior A E
Sherratt H S
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37 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1100521
Published
1968-12-00
Pages
521-7
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1187381
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1100521 PMC Full Text View journal details
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