Local anesthetics: effect of pH on activity.

Science (New York, N.Y.) ·Vol. 162 ·No. 3860 ·1968-12-20 ·Pages 1394-5

Ritchie JM, Ritchie BR

Abstract

Lidocaine and dibucaine are more effective in neutral than in alkaline solution when tested on the nonmyelinated fibers of the desheathed vagus nerve of the rabbit. Procaine, however, is more effective in alkaline solution. The activity of benzocaine is unaffected by pH. Both the charged and uncharged forms of local anesthetics thus seem capable of blocking conduction.

MeSH Terms

Action Potentials/drug effects Animals Benzocaine/pharmacology Chemical Phenomena Chemistry, Physical Depression, Chemical Dibucaine/pharmacology Hydrogen-Ion Concentration In Vitro Techniques Lidocaine/pharmacology Neural Conduction/drug effects Neurons/physiology Rabbits Vagus Nerve

Chemicals

Lidocaine Dibucaine Benzocaine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ritchie J M

Ritchie B R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3860.1394

Published

1968-12-20

Pages

1394-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3860.1394 View journal details

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