Noncycling tumor cells: mitogenic response to antilymphocytic serum.

Science (New York, N.Y.) ·Vol. 162 ·No. 3854 ·1968-11-08 ·Pages 698-9

DeCosse JJ, Gelfant S

Abstract

After continuous labeling with tritiated thymidine for a period several times the cell generation time, some ELD ascites cells remained unlabeled. Despite continued exposure to tritiated thymidine, unlabeled mitoses appeared promptly after administration of mouse antilymphocytic serum. Immunosuppression released some noncycling G(2) tumor cells into mitosis.

MeSH Terms

Animals Antilymphocyte Serum/pharmacology Autoradiography Carcinoma, Ehrlich Tumor/immunology DNA, Neoplasm/analysis Immune Sera/pharmacology Immunosuppressive Agents/pharmacology Lymphocytes/immunology Mice Mitosis Photometry Thymidine/metabolism Tritium

Chemicals

Antilymphocyte Serum DNA, Neoplasm Immune Sera Immunosuppressive Agents Tritium Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

DeCosse J J

Gelfant S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3854.698

Published

1968-11-08

Pages

698-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3854.698 View journal details

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Noncycling tumor cells: mitogenic response to antilymphocytic serum.

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