Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol.

Science (New York, N.Y.) ·Vol. 162 ·No. 3854 ·1968-11-08 ·Pages 690-1

Rubin E, Lieber CS

Abstract

The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.

MeSH Terms

Alcoholism Aniline Compounds/metabolism Animals Barbiturates/pharmacology Benzopyrenes/metabolism Depression, Chemical Drug Tolerance Enzyme Induction Ethanol/pharmacology Female Humans Liver/cytology,drug effects,enzymology Male Microsomes/drug effects,enzymology Mixed Function Oxygenases/antagonists & inhibitors,biosynthesis Pentobarbital/metabolism Rats Stimulation, Chemical

Chemicals

Aniline Compounds Barbiturates Benzopyrenes Ethanol Mixed Function Oxygenases Pentobarbital

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rubin E

Lieber C S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3854.690

Published

1968-11-08

Pages

690-1

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3854.690 View journal details

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Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol.

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