Mechanism of local anesthetic action of crystalline tetrodotoxin and its derivatives.

Abdomen/innervation Anesthesia, Local Animals Binding Sites Chemical Phenomena Chemistry, Physical Cornea/drug effects Crustacea Crystallization Dibucaine/pharmacology Guinea Pigs Hydrogen-Ion Concentration Mice Models, Biological Myelin Sheath/physiology Nerve Tissue/drug effects Neural Conduction/drug effects Procaine/pharmacology Rabbits Sensory Receptor Cells Skin/drug effects Temperature Tetrodotoxin/pharmacology,toxicity

Tetrodotoxin Procaine Dibucaine