In vitro perfused, non-isolated small intestine: ontogeny of transmural hydraulic permeability.

Pflugers Archiv : European journal of physiology ·Vol. 373 ·No. 2 ·1978-02-22 ·Pages 205-8

Wisser J, Horster M

Abstract

Net fluid flux and transmural hydrostatic hydraulic conductance (Lp) were measured in the rat ileum during postnatal ontogeny, utilizing a refined in vitro, capillary-perfused (non-isolated) preparation for free-flow studies. Volume absorption at low transmural pressure gradient (1-2 cmH2O) was 0.99 +/- 0.22 ml/g wet weight.hr in the mature ileum and 1.55 +/- 0.42 ml/g wwt.hr in the differentiating intestine. Hydrostatic hydraulic conductance of the mature ileum was 0.76 microliter/cm2.cm H2O.hr, indicating that normal hydrostatic pressure gradients are not important for modulation of intestinal absorption. In contrast, Lp was 3.82 microliter/cm2.cmH2O.hr in the differentiating ileu, suggesting a significant contribution of pressure-dependent solvent drag to isotonic solute absorption.

MeSH Terms

Aging Animals Animals, Newborn/metabolism Biological Transport, Active Hydrostatic Pressure Ileum/metabolism Rats Water/metabolism

Chemicals

Water

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wisser J

Horster M

References (15)

15 references, click to expand

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Article Info

Journal

Pflugers Archiv : European journal of physiology

Abbr.

Pflugers Arch

ISSN

0031-6768

DOI

10.1007/BF00584862

Published

1978-02-22

Pages

205-8

Language

English

Region

Germany

NLM ID

0154720

Subset

External Links

PubMed source DOI: 10.1007/BF00584862 View journal details

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In vitro perfused, non-isolated small intestine: ontogeny of transmural hydraulic permeability.

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