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PMID: 561313 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Initiation of check cell division by trypsin action at the cell surface.

Nature ·Vol. 268 ·No. 5621 ·1977-08-18 ·Pages 602-6

Carney DH, Cunningham DD

Abstract

Trypsin immobilised on polystyrene beads causes initiation of cell division which cannot be accounted for by trypsin released into the medium or into the cells. Also, initiation by soluble trypsin is inhibited by immobilised soybean trypsin inhibitor. These results demonstrate that trypsin can initiate proliferation at the cell surface.

MeSH Terms

Animals Cell Division/drug effects Cell Membrane/drug effects,metabolism Cells, Cultured Chick Embryo Enzymes, Immobilized/metabolism Mitogens Polystyrenes/pharmacology Solubility Trypsin/metabolism,pharmacology Trypsin Inhibitors/pharmacology

Chemicals

Enzymes, Immobilized Mitogens Polystyrenes Trypsin Inhibitors Trypsin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Carney D H

Cunningham D D

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/268602a0

Published

1977-08-18

Pages

602-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/268602a0 View journal details

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Initiation of check cell division by trypsin action at the cell surface.

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