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PMID: 558830 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immediate glycosylation of Sindbis virus membrane proteins.

Cell ·Vol. 10 ·No. 4 ·1977-04-00 ·Pages 659-68

Sefton BM

Abstract

The mechanism by which the membrane proteins of Sindbis virus are initially glycosylated during growth of the virus in chick cells was studied. The experiments suggest strongly that the two viral glycoproteins are glycosylated before release from the polysome, and that this glycosylation involves transfer of a large 1800 dalton oligosaccharide to the polypeptide chains. The donor of the oligosaccharide is most probably a lipid.

MeSH Terms

Animals Cell Line Chick Embryo Glucosamine/metabolism Glucose/metabolism Glycoproteins/biosynthesis Lipid Metabolism Mannose/metabolism Oligosaccharides/metabolism Peptide Biosynthesis Peptides/metabolism Polyribosomes/metabolism Sindbis Virus/growth & development,metabolism Viral Proteins/biosynthesis Virus Replication

Chemicals

Glycoproteins Oligosaccharides Peptides Viral Proteins Glucose Glucosamine Mannose

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Sefton B M

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(77)90099-x

Published

1977-04-00

Pages

659-68

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/0092-8674(77)90099-x View journal details

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